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Objective To explore the value of minimally invasive isthmic cerclage by laparoscope in the treatment of cervical insufficiency.Methods 22 patients with uterine insufficiency were selected,including 14 cases of non pregnancy and 8 cases of pregnancy,they all had transvaginal cervical cerclage surgery failure history,and took uterine minimalist cerclage by laparoscope,regularly followed-up and the clinical effect was observed.Results There were 14 cases of non-pregnancy,11 cases of post-operative pregnancy,35+3 to 40+3 weeks of gestation termination,average (38.6 ± 1.2) weeks of gestation,7 cases of gestation,37 +5 to 39 +4 weeks,mean (38.5 ±0.4) weeks.Conclusion Minimally invasive cervix cerclage by laparoscope is a good choice for those who have undergone transvaginal cerclage.
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0.05),while those of the cells treated with 6?10-5,6?10-6,6?10-7 mol/L of exemestane were significantly different from that of controls(P
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Background and purpose:Endometrial carcinoma is a common malignant tumour in women and expresses COX-2,CDK4;the expressions are associated with the development of the tumour. Mifepristone can inhibit the growth of the tumours, but its mechanisms are not very clear, We investigated the inhibitory effect of antiprogestins mifepristone n the growth of human endometrial carcinoma cell line HHUA xenografted in nude mice of and the expressions of COX-2,CDK4,the purpose was to find out whether or not mifepristone could influence the expressions of COX-2,CDK4. Methods:Human endometrial carcinoma HHUA cells were cultured in vitro.The models of xenografted tumor were established by the transplantation of human endometrial carcinoma HHUA cell on nude mice. The nude mice were randomly divided into two groups to receive either refined peanut oil (control group), or daily mifepristone for six weeks, respectively . The sizes of xenograft were measured in the pre-and post-treatment. The changes of morphology were observed by glass microscopy. The positive immunostaining for COX-2 and CDK4 were evaluated semiquantitatively by using an immunohistochemical scoring system (HSCORE) that it incorporated both the intensity and the distribution of specific staining.Results:After 6 weeks of treatment , the size of the xenografts in MIF group were 115.25?10.97 mm 3 ,compared with 313.25?43.92 mm 3 in the control group (P